Publications

2025

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    Peptide-functionalized nanoparticles for brain-targeted therapeutics
    Sophia Tang , Emily L. Han and Michael J. Mitchell
    Drug Delivery and Translational Research, Mar 2025
    Paper
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    Gumbel-Softmax Flow Matching with Straight-Through Guidance for Controllable Biological Sequence Generation
    Sophia Tang , Yinuo Zhang , Alexander Tong and Pranam Chatterjee
    arXiv, Preprint, Mar 2025
    Paper

2024

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    PepTune: De Novo Generation of Therapeutic Peptides with Multi-Objective-Guided Discrete Diffusion
    Sophia Tang , Yinuo Zhang and Pranam Chatterjee
    arXiv, Preprint [In Review], Dec 2024
    Paper Article Code
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    Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain
    Emily L. Han , Sophia Tang , Dongyoon Kim , Amanda M. Murray , Kelsey L. Swingle , Alex G. Hamilton , Kaitlin Mrksich , Marshall S. Padilla , Rohan Palanki , Jacqueline J. Li and Michael J. Mitchell
    Nano Letters, American Chemical Society (ACS), Dec 2024
    Paper
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    Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood–Brain Barrier Transfection and Crossing
    Emily L. Han , Marshall S. Padilla , Rohan Palanki , Dongyoon Kim , Kaitlin Mrksich , Jacqueline J. Li , Sophia Tang , Il-Chul Yoon and Michael J. Mitchell
    Nano Letters, American Chemical Society (ACS), Jan 2024
    Paper
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    Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing
    Rohan Palanki , Emily L. Han , Amanda M. Murray , Rohin Maganti , Sophia Tang , Kelsey L. Swingle , Dongyoon Kim , Hannah Yamagata , Hannah C. Safford , Kaitlin Mrksich , William H. Peranteau and Michael J. Mitchell
    Lab on a Chip, Jan 2024
    Paper