Publications

* Indicates equal contribution

2025

  1. mrnautilus.png
    Multi-Objective-Guided Generative Design of mRNA with Therapeutic Properties
    Sawan Patel* , Sophia Tang* , Yinuo Zhang , Pranam Chatterjee and Sherwood Yao
    ICML 2025 Generative AI and Biology (GenBio) Workshop, Preprint, Jul 2025
    PDF Poster
  2. branchsbm.png
    Branched Schrödinger Bridge Matching
    Sophia Tang , Yinuo Zhang , Alexander Tong and Pranam Chatterjee
    arXiv, Preprint, Jun 2025
    Paper Code Poster
  3. mog-dfm.png
    Multi-Objective-Guided Discrete Flow Matching for Controllable Biological Sequence Design
    Tong Chen , Yinuo Zhang , Sophia Tang and Pranam Chatterjee
    arXiv, Preprint, May 2025
    Paper Code
  4. ddtr.jpg
    Peptide-functionalized nanoparticles for brain-targeted therapeutics
    Sophia Tang , Emily L. Han and Michael J. Mitchell
    Drug Delivery and Translational Research, Mar 2025
    Paper
  5. guidance.png
    Gumbel-Softmax Flow Matching with Straight-Through Guidance for Controllable Biological Sequence Generation
    Sophia Tang , Yinuo Zhang , Alexander Tong and Pranam Chatterjee
    arXiv, Preprint, Mar 2025
    Paper Poster

2024

  1. peptune-vid.gif
    PepTune: De Novo Generation of Therapeutic Peptides with Multi-Objective-Guided Discrete Diffusion
    Sophia Tang* , Yinuo Zhang* and Pranam Chatterjee
    42nd International Conference on Machine Learning (ICML 2025), Dec 2024
    Paper Article Code Poster
  2. nanoletters.jpeg
    Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain
    Emily L. Han , Sophia Tang , Dongyoon Kim , Amanda M. Murray , Kelsey L. Swingle , Alex G. Hamilton , Kaitlin Mrksich , Marshall S. Padilla , Rohan Palanki , Jacqueline J. Li and Michael J. Mitchell
    Nano Letters, American Chemical Society (ACS), Dec 2024
    Paper
  3. predictive.jpeg
    Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood–Brain Barrier Transfection and Crossing
    Emily L. Han , Marshall S. Padilla , Rohan Palanki , Dongyoon Kim , Kaitlin Mrksich , Jacqueline J. Li , Sophia Tang , Il-Chul Yoon and Michael J. Mitchell
    Nano Letters, American Chemical Society (ACS), Jan 2024
    Paper
  4. optimized.jpeg
    Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing
    Rohan Palanki , Emily L. Han , Amanda M. Murray , Rohin Maganti , Sophia Tang , Kelsey L. Swingle , Dongyoon Kim , Hannah Yamagata , Hannah C. Safford , Kaitlin Mrksich , William H. Peranteau and Michael J. Mitchell
    Lab on a Chip, Jan 2024
    Paper