Sophia Tang
sophtang [at] seas.upenn.edu
Hi! I am a third-year undergraduate student at the University of Pennsylvania conducting research in generative ML for scientific discovery. Aside from research, I study computer science and statistics in the Jerome Fisher Program in Management & Technology.
Currently, I’m part of the Chatterjee Lab, developing theoretical ML frameworks for biological design, and the Mitchell Lab, designing lipid nanoparticle (LNP)-based delivery vehicles to transport mRNA across the blood-brain barrier.
My research ranges from developing theoretical Schrödinger bridge frameworks for generative modelling of branching and interacting particle systems to multi-objective RL and guidance techniques for discrete diffusion - but I’m always exploring new theoretical ideas and thinking about interesting problems to apply them to!
I also write long-form tutorial papers on foundational topics in machine learning and shorter technical articles on my Substack, Alchemy Bio. I recently released Foundations of Schrödinger Bridges for Generative Modeling (220 pages) and A Complete Guide to Spherical Equivariant Graph Transformers (99 pages), which aim to break down complex theoretical concepts for a broad audience.
If any of these topics sparks your interest, I would love to connect via LinkedIn or X.
Updates
| Jun 15, 2026 | A2D2 🃏 and mRNAutilus 🧬 are out! A new framework for reward-alignment of any-length discrete diffusion with adaptive decoding, and an experimentally-validated multi-objective mRNA generative model! |
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| Mar 20, 2026 | New tutorial paper on the Foundations of Schrödinger Bridges for Generative Modeling (220 pages, 24 figures) is out on arXiv! |
| Jan 26, 2026 | Branched Schrödinger Bridge Matching is accepted at ICLR 2026 main! 🌳🧫 Looking forward to presenting in Rio! 🇧🇷 |
| Jan 23, 2026 | Awarded the CRA Outstanding Undergraduate Researcher Award (1 of 8 across North America)! Read the news article here! |
| Nov 11, 2025 | EntangledSBM is out! Read our paper on simulating interacting multi-particle systems with a novel Schrödinger bridge matching framework! |
Selected Publications
For a full list, see my publications page or google scholar profile.
